Site-Specific Coupling and Sterically Controlled Formation of Multimeric Antibody Fab Fragments with Unnatural Amino Acids

Immunoconjugates and multispecific antibodies are rapidly emerging as highly potent experimental therapeutics against cancer. We have developed a method to incorporate an unnatural amino acid, p-acetylphenylalanine (pAcPhe) into an antibody antigen binding fragment (Fab) targeting HER2 (human epider...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Hutchins, Benjamin M., Kazane, Stephanie A., Staflin, Karin, Forsyth, Jane S., Felding-Habermann, Brunhilde, Schultz, Peter G., Smider, Vaughn V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278757/
https://ncbi.nlm.nih.gov/pubmed/21237172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.01.011
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