Site-Specific Coupling and Sterically Controlled Formation of Multimeric Antibody Fab Fragments with Unnatural Amino Acids

Immunoconjugates and multispecific antibodies are rapidly emerging as highly potent experimental therapeutics against cancer. We have developed a method to incorporate an unnatural amino acid, p-acetylphenylalanine (pAcPhe) into an antibody antigen binding fragment (Fab) targeting HER2 (human epider...

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Detalles Bibliográficos
Publicado en:J Mol Biol
Main Authors: Hutchins, Benjamin M., Kazane, Stephanie A., Staflin, Karin, Forsyth, Jane S., Felding-Habermann, Brunhilde, Schultz, Peter G., Smider, Vaughn V.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278757/
https://ncbi.nlm.nih.gov/pubmed/21237172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.01.011
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