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Synthesis of Bispecific Antibodies with Genetically Encoded Unnatural Amino Acids

Bispecific antibodies were constructed using genetically encoded unnatural amino acids with orthogonal chemical reactivity. A two-step process afforded homogeneous products in excellent yield. Using this approach, we synthesized an anti-HER2/anti-CD3 bispecific antibody, which efficiently crosslinke...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Kim, Chan Hyuk, Axup, Jun Y., Dubrovska, Anna, Kazane, Stephanie A., Hutchins, Benjamin A., Wold, Erik D., Smider, Vaughn V., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299457/
https://ncbi.nlm.nih.gov/pubmed/22642368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303904e
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