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Synthesis of Bispecific Antibodies with Genetically Encoded Unnatural Amino Acids
Bispecific antibodies were constructed using genetically encoded unnatural amino acids with orthogonal chemical reactivity. A two-step process afforded homogeneous products in excellent yield. Using this approach, we synthesized an anti-HER2/anti-CD3 bispecific antibody, which efficiently crosslinke...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4299457/ https://ncbi.nlm.nih.gov/pubmed/22642368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303904e |
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