Self-Assembled Antibody Multimers through Peptide Nucleic Acid Conjugation

With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and evaluate bispecific or higher order multispecific molecules could facilitate the discovery of new therapeutic agents. Here we show that unnatural amino acids (UAAs) with orthogonal chemical reactivity can...

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Bibliographische Detailangaben
Hauptverfasser: Kazane, Stephanie A., Axup, Jun Y, Kim, Chan Hyuk, Ciobanu, Mihai, Wold, Erik D., Barluenga, Sofia, Hutchins, Benjamin A., Schultz, Peter G., Winssinger, Nicolas, Smider, Vaughn V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951380/
https://ncbi.nlm.nih.gov/pubmed/23210862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309505c
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