An Immunosuppressive Antibody-Drug Conjugate

We have developed a novel antibody drug-conjugate (ADC) which can selectively deliver the Lck inhibitor dasatinib to human T lymphocytes. This ADC is based on a humanized antibody which selectively binds with high affinity to CXCR4, an antigen that is selectively expressed on hematopoietic cells. Th...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wang, Rongsheng E., Liu, Tao, Wang, Ying, Cao, Yu, Du, Jintang, Luo, Xiaozhou, Deshmukh, Vishal, Kim, Chan Hyuk, Lawson, Brian R., Tremblay, Matthew S., Young, Travis S., Kazane, Stephanie A., Wang, Feng, Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472444/
https://ncbi.nlm.nih.gov/pubmed/25699419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00620
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