An Epitope-Specific Respiratory Syncytial Virus Vaccine based on an Antibody Scaffold

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children. We have generated an epitope-specific RSV vaccine by grafting a neutralizing epitope (F-epitope) in its native conformation into an immunoglobulin scaffold. The resulting antibody fusion exhibited...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Luo, Xiaozhou, Liu, Tao, Wang, Ying, Jia, Haiqun, Zhang, Yuhan, Caballero, Dawna, Du, Juanjuan, Wang, Rongsheng E., Wang, Danling, Schultz, Peter G., Wang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715490/
https://ncbi.nlm.nih.gov/pubmed/26434555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507928
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