Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists

On the basis of the 3D structure of a bovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have developed a versatile approach for generating human or humanized antibody agonists with excellent pharmacological properties. Using human growth hormone (hGH) and hum...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Tao, Zhang, Yong, Liu, Yan, Wang, Ying, Jia, Haiqun, Kang, Mingchao, Luo, Xiaozhou, Caballero, Dawna, Gonzalez, Jose, Sherwood, Lance, Nunez, Vanessa, Wang, Danling, Woods, Ashley, Schultz, Peter G., Wang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321239/
https://ncbi.nlm.nih.gov/pubmed/25605877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423668112
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados