Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery

Antidiabetic treatments aiming to reduce body weight are currently gaining increased interest. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist administered twice daily via s.c. injection, improves glycemic control, often with associated weight reduction. To further improve the therapeu...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yang, Peng-Yu, Zou, Huafei, Chao, Elizabeth, Sherwood, Lance, Nunez, Vanessa, Keeney, Michael, Ghartey-Tagoe, Esi, Ding, Zhongli, Quirino, Herlinda, Luo, Xiaozhou, Welzel, Gus, Chen, Guohua, Singh, Parminder, Woods, Ashley K., Schultz, Peter G., Shen, Weijun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839405/
https://ncbi.nlm.nih.gov/pubmed/27035989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601653113
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