Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones

Recent studies have suggested that modulation of two or more signaling pathways can achieve substantial weight loss and glycemic stability. We have developed an approach to the generation of bi-functional antibody agonists that activate leptin receptor and GLP-1 receptor. Leptin was fused into the c...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Liu, Yan, Wang, Ying, Zhang, Yong, Liu, Tao, Jia, Haiqun, Zou, Huafei, Fu, Qiangwei, Zhang, Yuhan, Lu, Lucy, Chao, Elizabeth, Parker, Holly, Nguyen-Tran, Van, Shen, Weijun, Wang, Danling, Schultz, Peter G., Wang, Feng
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148668/
https://ncbi.nlm.nih.gov/pubmed/27704775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00630
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