Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones

Recent studies have suggested that modulation of two or more signaling pathways can achieve substantial weight loss and glycemic stability. We have developed an approach to the generation of bi-functional antibody agonists that activate leptin receptor and GLP-1 receptor. Leptin was fused into the c...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Liu, Yan, Wang, Ying, Zhang, Yong, Liu, Tao, Jia, Haiqun, Zou, Huafei, Fu, Qiangwei, Zhang, Yuhan, Lu, Lucy, Chao, Elizabeth, Parker, Holly, Nguyen-Tran, Van, Shen, Weijun, Wang, Danling, Schultz, Peter G., Wang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148668/
https://ncbi.nlm.nih.gov/pubmed/27704775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00630
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