Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

A variable region fusion strategy was used to generate an immunosuppressive antibody based on a novel “stalk-knob” structural motif in the ultralong complementary-determining region (CDR) of a bovine antibody. The potent Kv1.3 channel inhibitory peptides Moka1-toxin and Vm24-toxin were grafted into...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Rongsheng E., Wang, Ying, Zhang, Yuhan, Gabrelow, Chase, Zhang, Yong, Chi, Victor, Fu, Qiangwei, Luo, Xiaozhou, Wang, Danling, Joseph, Sean, Johnson, Kristen, Chatterjee, Arnab K., Wright, Timothy M., Nguyen-Tran, Vân T. B., Teijaro, John, Theofilopoulos, Argyrios N., Schultz, Peter G., Wang, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068325/
https://ncbi.nlm.nih.gov/pubmed/27663736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612803113
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