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Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity
The trans-translation pathway for protein tagging and ribosome release plays a critical role for viability and virulence in a wide range of pathogens but is not found in animals. To explore the use of trans-translation as a target for antibiotic development, a high-throughput screen and secondary sc...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690859/ https://ncbi.nlm.nih.gov/pubmed/23733947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302816110 |
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