The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5

Por Hsu, Mei-Hui, Savas, Uzen, Johnson, Eric F.
Publicado no Mol Pharmacol (2018)

Severe Microcytic Anemia but Increased Erythropoiesis in Mice Lacking Hfe or Tfr2 and Tmprss6

Por Lee, Pauline, Hsu, Mei-Hui, Welser-Alves, Jennifer, Peng, Hongfan
Publicado em 2012

Structural Insight into the Altered Substrate Specificity of Human Cytochrome P450 2A6 Mutants: Structures of human P450 2A6 mutants

Por Sansen, Stefaan, Hsu, Mei-Hui, Stout, C. David, Johnson, Eric F.
Publicado em 2007

Genistein, Resveratrol, and 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Induce Cytochrome P450 4F2 Expression through an AMP-Activated Protein Kinase-Dependent Pathway

Por Hsu, Mei-Hui, Savas, Üzen, Lasker, Jerome M., Johnson, Eric F.
Publicado em 2011

Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound

Por Wang, An, Savas, Uzen, Hsu, Mei-Hui, Stout, C. David, Johnson, Eric F.
Publicado em 2012

The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation

Por Hsu, Mei-Hui, Baer, Brian R., Rettie, Allan E., Johnson, Eric F.
Publicado no J Biol Chem (2017)

Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1

Por Jennings, Gareth K., Hsu, Mei-Hui, Shock, Lisa S., Johnson, Eric F., Hackett, John C
Publicado no J Biol Chem (2018)

20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOR...

Por Savas, Üzen, Wei, Shouzou, Hsu, Mei-Hui, Falck, John R., Guengerich, F. Peter, Capdevila, Jorge H., Johnson, Eric F.
Publicado no J Biol Chem (2016)

Opposing Roles of Peroxisome Proliferator-activated Receptor α and Growth Hormone in the Regulation of CYP4A11 Expression in a Transgenic Mouse Model

Por Savas, Üzen, Machemer, Daniel E. W., Hsu, Mei-Hui, Gaynor, Pryce, Lasker, Jerome M., Tukey, Robert H., Johnson, Eric F.
Publicado em 2009

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes

Por Liu, Renhe, Lyu, Xiaoxuan, Batt, Sarah M, Hsu, Mei‐Hui, Harbut, Michael B, Vilchèze, Catherine, Cheng, Bo, Ajayi, Kehinde, Yang, Baiyuan, Yang, Yun, Guo, Hui, Lin, Changyou, Gan, Fei, Wang, Chen, Franzblau, Scott G., Jacobs, William R., Besra, Gurdyal S., Johnson, Eric F., Petrassi, Mike, Chatterjee, Arnab K., Fütterer, Klaus, Wang, Feng
Publicado no Angew Chem Int Ed Engl (2017)

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Por Butler, Christopher R., Ogilvie, Kevin, Martinez-Alsina, Luis, Barreiro, Gabriela, Beck, Elizabeth M., Nolan, Charles E., Atchison, Kevin, Benvenuti, Eric, Buzon, Leanne, Doran, Shawn, Gonzales, Cathleen, Helal, Christopher J., Hou, Xinjun, Hsu, Mei-Hui, Johnson, Eric F., Lapham, Kimberly, Lanyon, Lorraine, Parris, Kevin, O’Neill, Brian T., Riddell, David, Robshaw, Ashley, Vajdos, Felix, Brodney, Michael A.
Publicado no J Med Chem (2016)