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Structural Insight into the Altered Substrate Specificity of Human Cytochrome P450 2A6 Mutants: Structures of human P450 2A6 mutants
Human P450 2A6 displays a small active site that is well adapted for the oxidation of small planar substrates. Mutagenesis of CYP2A6 resulted in an increased catalytic efficiency for indole biotransformation to pigments and conferred a capacity to oxidize substituted indoles (Wu, Z.-L., Podust, L.M....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773796/ https://ncbi.nlm.nih.gov/pubmed/17540336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.04.028 |
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