Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice

Por Chen, Shujuan, Tukey, Robert H.
Publicado no Drug Metab Dispos (2018)

NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice

Por Paszek, Miles, Tukey, Robert H.
Publicado no Drug Metab Dispos (2020)

Triclosan: A Widespread Environmental Toxicant with Many Biological Effects

Por Yueh, Mei-Fei, Tukey, Robert H.
Publicado no Annu Rev Pharmacol Toxicol (2016)

Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in hum...

Por Fujiwara, Ryoichi, Yoda, Emiko, Tukey, Robert H.
Publicado no Drug Metab Pharmacokinet (2017)

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus

Por Fujiwara, Ryoichi, Nguyen, Nghia, Chen, Shujuan, Tukey, Robert H.
Publicado em 2010

Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to Hyperbilirubinemia

Por FUJIWARA, RYOICHI, CHEN, SHUJUAN, KARIN, MICHAEL, TUKEY, ROBERT H.
Publicado em 2011

Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia

Por Shibuya, Ayako, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Publicado em 2013

Glucuronidation of Drugs and Drug-Induced Toxicity in Humanized UDP-Glucuronosyltransferase 1 Mice

Por Kutsuno, Yuki, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Publicado em 2014

Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia

Por Fujiwara, Ryoichi, Maruo, Yoshihiro, Chen, Shujuan, Tukey, Robert H.
Publicado no Toxicol Appl Pharmacol (2015)

Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain()

Por Sakamoto, Masaya, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Publicado no Drug Metab Pharmacokinet (2015)

Prediction of drug-induced liver injury using keratinocytes

Por Hirashima, Rika, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Publicado no J Appl Toxicol (2017)

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Por Yueh, Mei-Fei, Chen, Shujuan, Nguyen, Nghia, Tukey, Robert H.
Publicado em 2014

Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia

Por Yueh, Mei-Fei, Chen, Shujuan, Nguyen, Nghia, Tukey, Robert H.
Publicado no Mol Pharmacol (2017)

Pregnane-X-Receptor Controls Hepatic Glucuronidation During Pregnancy and Neonatal Development in Humanized UGT1 Mice

Por Chen, Shujuan, Yueh, Mei-Fei, Evans, Ronald M, Tukey, Robert H
Publicado em 2012

Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia

Por Aoshima, Naoya, Fujie, Yoshiko, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Publicado em 2014

Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes

Por Kutsuno, Yuki, Sumida, Kyohei, Itoh, Tomoo, Tukey, Robert H, Fujiwara, Ryoichi
Publicado em 2013

Severe neonatal hyperbilirubinemia in Crigler‐Najjar syndrome model mice can be reversed with zinc protoporphyrin

Por Fujiwara, Ryoichi, Mitsugi, Ryo, Uemura, Asuka, Itoh, Tomoo, Tukey, Robert H.
Publicado no Hepatol Commun (2017)

Triclocarban Mediates Induction of Xenobiotic Metabolism through Activation of the Constitutive Androstane Receptor and the Estrogen Receptor Alpha

Por Yueh, Mei-Fei, Li, Tao, Evans, Ronald M., Hammock, Bruce, Tukey, Robert H.
Publicado em 2012

Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress

Por Yoda, Emiko, Paszek, Miles, Konopnicki, Camille, Fujiwara, Ryoichi, Chen, Shujuan, Tukey, Robert H.
Publicado no Sci Rep (2017)

Trovafloxacin acyl-glucuronide induces chemokine (C-X-C motif) ligand 2 in HepG2 cells

Por Mitsugi, Ryo, Sumida, Kyohei, Fujie, Yoshiko, Tukey, Robert H., Itoh, Tomoo, Fujiwara, Ryoichi
Publicado no Biol Pharm Bull (2016)