Glucuronidation of Drugs and Drug-Induced Toxicity in Humanized UDP-Glucuronosyltransferase 1 Mice

UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various drugs. Although experimental rodents are used in preclinical studies to predict glucuronidation and toxicity of drugs in humans, species differences in glucuronidation and drug-induced...

Full description

Saved in:
Bibliographic Details
Main Authors: Kutsuno, Yuki, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053997/
https://ncbi.nlm.nih.gov/pubmed/24764149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.057083
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items