Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Biological and signaling events that connect developmentally induced hyperbilirubinemia to bilirubin-induced neurological dysfunction (BIND) and CNS toxicity in humans are poorly understood. In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme responsible for bilirubin glucuronida...

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Main Authors: Yueh, Mei-Fei, Chen, Shujuan, Nguyen, Nghia, Tukey, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931032/
https://ncbi.nlm.nih.gov/pubmed/24403077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518613
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