Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice

Neonatal hyperbilirubinemia and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the ability to metabolize bilirubin. It is generally believed that acute neonatal forms of hyperbilirubinemia develop due to an...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Chen, Shujuan, Tukey, Robert H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Special Section – New Models in Drug Metabolism and Transport
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199628/
https://ncbi.nlm.nih.gov/pubmed/30093417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.083212
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