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Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia

Humanized UDP-glucuronosyltransferase (UGT)-1 (hUGT1) mice encode the UGT1 locus including the UGT1A1 gene. During neonatal development, delayed expression of the UGT1A1 gene leads to hyperbilirubinemia as determined by elevated levels of total serum bilirubin (TSB). We show in this report that the...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Liu, Miao, Chen, Shujuan, Yueh, Mei-Fei, Fujiwara, Ryoichi, Konopnicki, Camille, Hao, Haiping, Tukey, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010383/
https://ncbi.nlm.nih.gov/pubmed/27060662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.04.003
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