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Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia

Humanized UDP-glucuronosyltransferase (UGT)-1 (hUGT1) mice encode the UGT1 locus including the UGT1A1 gene. During neonatal development, delayed expression of the UGT1A1 gene leads to hyperbilirubinemia as determined by elevated levels of total serum bilirubin (TSB). We show in this report that the...

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Publicat a:Biochem Pharmacol
Autors principals: Liu, Miao, Chen, Shujuan, Yueh, Mei-Fei, Fujiwara, Ryoichi, Konopnicki, Camille, Hao, Haiping, Tukey, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010383/
https://ncbi.nlm.nih.gov/pubmed/27060662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.04.003
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