Загрузка...
Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1
Cytochrome P450 4B1 (4B1) functions in both xenobiotic and endobiotic metabolism. An ester linkage between Glu-310 in 4B1 and the 5-methyl group of heme facilitates preferential hydroxylation of terminal (ω) methyl groups of hydrocarbons (HCs) and fatty acids compared with ω–1 sites bearing weaker C...
Сохранить в:
| Опубликовано в: : | J Biol Chem |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065186/ https://ncbi.nlm.nih.gov/pubmed/29858244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004044 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|