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Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1
Cytochrome P450 4B1 (4B1) functions in both xenobiotic and endobiotic metabolism. An ester linkage between Glu-310 in 4B1 and the 5-methyl group of heme facilitates preferential hydroxylation of terminal (ω) methyl groups of hydrocarbons (HCs) and fatty acids compared with ω–1 sites bearing weaker C...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065186/ https://ncbi.nlm.nih.gov/pubmed/29858244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004044 |
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