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Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1
The atomic structure of human P450 1B1 was determined by x-ray crystallography to 2.7 Å resolution with α-naphthoflavone (ANF) bound in the active site cavity. Although the amino acid sequences of human P450s 1B1 and 1A2 have diverged significantly, both enzymes exhibit narrow active site cavities,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037686/ https://ncbi.nlm.nih.gov/pubmed/21147782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204420 |
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