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Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1

The atomic structure of human P450 1B1 was determined by x-ray crystallography to 2.7 Å resolution with α-naphthoflavone (ANF) bound in the active site cavity. Although the amino acid sequences of human P450s 1B1 and 1A2 have diverged significantly, both enzymes exhibit narrow active site cavities,...

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Библиографические подробности
Главные авторы: Wang, An, Savas, Uzen, Stout, C. David, Johnson, Eric F.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037686/
https://ncbi.nlm.nih.gov/pubmed/21147782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204420
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