Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in vitro combined with rifampicin or isoniazid. In a...

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Detalhes bibliográficos
Main Authors: Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M., Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E., Franzblau, Scott, Chatterjee, Arnab K., Johnsson, Kai, Mikusova, Katarina, Besra, Gurdyal S., Fütterer, Klaus, Robbins, Scott H., Barnes, S. Whitney, Walker, John R., Jacobs, William R., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703973/
https://ncbi.nlm.nih.gov/pubmed/23776209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309171110
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