Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in vitro combined with rifampicin or isoniazid. In a...

Full description

Saved in:
Bibliographic Details
Main Authors: Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M., Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E., Franzblau, Scott, Chatterjee, Arnab K., Johnsson, Kai, Mikusova, Katarina, Besra, Gurdyal S., Fütterer, Klaus, Robbins, Scott H., Barnes, S. Whitney, Walker, John R., Jacobs, William R., Schultz, Peter G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703973/
https://ncbi.nlm.nih.gov/pubmed/23776209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309171110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items