Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in vitro combined with rifampicin or isoniazid. In a...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M., Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E., Franzblau, Scott, Chatterjee, Arnab K., Johnsson, Kai, Mikusova, Katarina, Besra, Gurdyal S., Fütterer, Klaus, Robbins, Scott H., Barnes, S. Whitney, Walker, John R., Jacobs, William R., Schultz, Peter G.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
PNAS Plus
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703973/
https://ncbi.nlm.nih.gov/pubmed/23776209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309171110
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