A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Us...

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Publicado en:mBio
Autores principales: Dhingra, Satish K., Redhi, Devasha, Combrinck, Jill M., Yeo, Tomas, Okombo, John, Henrich, Philipp P., Cowell, Annie N., Gupta, Purva, Stegman, Matthew L., Hoke, Jonathan M., Cooper, Roland A., Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J., Fidock, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424201/
https://ncbi.nlm.nih.gov/pubmed/28487425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00303-17
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