Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the Plasmodium falciparum chloroquine resistance transporter PfCRT following...

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Publicado en:Nat Commun
Main Authors: Ross, Leila S., Dhingra, Satish K., Mok, Sachel, Yeo, Tomas, Wicht, Kathryn J., Kümpornsin, Krittikorn, Takala-Harrison, Shannon, Witkowski, Benoit, Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095916/
https://ncbi.nlm.nih.gov/pubmed/30115924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05652-0
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