Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, unti...

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發表在:Nature
Main Authors: Kim, Jonathan, Tan, Yong Zi, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie, Hagenah, Laura M., Giacometti, Sabrina I., Warren, Audrey L., Nosol, Kamil, Roepe, Paul D., Potter, Clinton S., Carragher, Bridget, Kossiakoff, Anthony A., Quick, Matthias, Fidock, David A., Mancia, Filippo
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911266/
https://ncbi.nlm.nih.gov/pubmed/31776516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1795-x
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