Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

Ideally antimalarial drugs can be developed which target multiple life cycle stages, thus impacting prevention, treatment and transmission of disease. Here we introduce 4-(1H)-quinolone-3-diarylethers that are selectively potent inhibitors of the parasite’s mitochondrial cytochrome bc(1) complex. Th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Transl Med
Prif Awduron: Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227885/
https://ncbi.nlm.nih.gov/pubmed/23515079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005029
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