Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: an Immediate Access to Diverse 3-Aryl-4(1H)-Quinolones

Por Monastyrskyi, Andrii, Namelikonda, Niranjan K., Manetsch, Roman
Publicado no J Org Chem (2015)

4(1H)-Pyridone and 4(1H)-Quinolone Derivatives as Antimalarials with Erythrocytic, Exoerythrocytic, and Transmission Blocking Activities

Por Monastyrskyi, Andrii, Kyle, Dennis E., Manetsch, Roman
Publicado no Curr Top Med Chem (2014)

Bcl-X(L)-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides

Por Hu, Xiangdong, Sun, Jiazhi, Wang, Hong-Gang, Manetsch, Roman
Publicado em 2008

Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry

Por Radić, Zoran, Manetsch, Roman, Fournier, Didier, Sharpless, K. Barry, Taylor, Palmer
Publicado em 2008

Screening of Protein-Protein Interaction Modulators via Sulfo-Click Kinetic Target-Guided Synthesis

Por Kulkarni, Sameer S., Hu, Xiangdong, Doi, Kenichiro, Wang, Hong-Gang, Manetsch, Roman
Publicado em 2011

Synthesis and Evaluation of a Novel Adenosine-Ribose Probe for Global-Scale Profiling of Nucleoside and Nucleotide-Binding Proteins

Por Mahajan, Shikha, Manetsch, Roman, Merkler, David J., Stevens Jr., Stanley M.
Publicado no PLoS One (2015)

In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery

Por Campbell, Christopher O., Santiago, Daniel N., Guida, Wayne C., Manetsch, Roman, Adams, John H.
Publicado no Chem Biol Drug Des (2014)

SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines

Por Zhu, Xiaohua, Van Horn, Kurt S., Barber, Megan, Yang, Sihyung, Wang, Michael Zhuo, Manetsch, Roman, Werbovetz, Karl A.
Publicado no Bioorg Med Chem (2015)

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni

Por Sáenz, Fabián E., LaCrue, Alexis N., Cross, R. Matthew, Maignan, Jordany R., Udenze, Kenneth O., Manetsch, Roman, Kyle, Dennis E.
Publicado em 2013

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

Por Roberts, Bracken F., Iyamu, Iredia D., Lee, Sukjun, Lee, Eunyoung, Ayong, Lawrence, Kyle, Dennis E., Yuan, Yu, Manetsch, Roman, Chakrabarti, Debopam
Publicado no Int J Parasitol Drugs Drug Resist (2016)

4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei

Por LaCrue, Alexis N., Sáenz, Fabián E., Cross, R. Matthew, Udenze, Kenneth O., Monastyrskyi, Andrii, Stein, Steven, Mutka, Tina S., Manetsch, Roman, Kyle, Dennis E.
Publicado em 2013

Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines

Por Van Horn, Kurt S., Zhu, Xiaohua, Pandharkar, Trupti, Yang, Sihyung, Vesely, Brian, Vanaerschot, Manu, Dujardin, Jean-Claude, Rijal, Suman, Kyle, Dennis E., Wang, Michael Zhuo, Werbovetz, Karl A., Manetsch, Roman
Publicado em 2014

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

Por Cross, R. Matthew, Flanigan, David L., Monastyrskyi, Andrii, LaCrue, Alexis N., Sáenz, Fabián E., Maignan, Jordany R., Mutka, Tina S., White, Karen L., Shackleford, David M., Bathurst, Ian, Fronczek, Frank R, Wojtas, Lukasz, Guida, Wayne C., Charman, Susan A., Burrows, Jeremy N., Kyle, Dennis E., Manetsch, Roman
Publicado no J Med Chem (2014)

Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

Por Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
Publicado no Sci Transl Med (2013)