Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (...

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Detalhes bibliográficos
Publicado no:Int J Parasitol Drugs Drug Resist
Main Authors: Roberts, Bracken F., Iyamu, Iredia D., Lee, Sukjun, Lee, Eunyoung, Ayong, Lawrence, Kyle, Dennis E., Yuan, Yu, Manetsch, Roman, Chakrabarti, Debopam
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805781/
https://ncbi.nlm.nih.gov/pubmed/27054067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2016.02.004
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