Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

[Image: see text] The historical antimalarial compound endochin served as a structural lead for optimization. Endochin-like quinolones (ELQ) were prepared by a novel chemical route and assessed for in vitro activity against multidrug resistant strains of Plasmodium falciparum and against malaria inf...

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Główni autorzy: Nilsen, Aaron, Miley, Galen P., Forquer, Isaac P., Mather, Michael W., Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M., Stickles, Allison M., Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L., Hinrichs, David J., Winter, Rolf W., Charman, Susan A., Zakharov, Lev N., Bathurst, Ian, Burrows, Jeremy N., Vaidya, Akhil B., Riscoe, Michael K.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2014
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018401/
https://ncbi.nlm.nih.gov/pubmed/24720377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500147k
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