Inhibition of Cytochrome bc(1) as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

Single-dose therapies for malaria have been proposed as a way to reduce the cost and increase the effectiveness of antimalarial treatment. However, no compound to date has shown single-dose activity against both the blood-stage Plasmodium parasites that cause disease and the liver-stage parasites th...

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Udgivet i:Am J Trop Med Hyg
Main Authors: Stickles, Allison M., Ting, Li-Min, Morrisey, Joanne M., Li, Yuexin, Mather, Michael W., Meermeier, Erin, Pershing, April M., Forquer, Isaac P., Miley, Galen P., Pou, Sovitj, Winter, Rolf W., Hinrichs, David J., Kelly, Jane X., Kim, Kami, Vaidya, Akhil B., Riscoe, Michael K., Nilsen, Aaron
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Tropical Medicine and Hygiene 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458825/
https://ncbi.nlm.nih.gov/pubmed/25918204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0553
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