Interactions of Human Melanocortin 4 Receptor with Non Peptide and Peptide Agonists

Por Pogozheva, Irina D., Chai, Biao-Xin, Lomize, Andrei L., Fong, Tung M., Weinberg, David H., Nargund, Ravi P., Mulholland, Michael W., Gantz, Ira, Mosberg, Henry I.
Publicado em 2005

Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

Por Li, Derun, Wu, Zhicai, Yu, Yang, Ball, Richard G., Guo, Liangqin, Sherer, Edward, He, Shuwen, Hong, Qingmei, Lai, Zhong, Qi, Hongbo, Truong, Quang, Yang, David X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Trujillo, Maria, Pachanski, Michele, Eiermann, George J., Howard, Andrew D., Zhou, Yun-Ping, Zhang, Bei B., Nargund, Ravi P., Hagmann, William K.
Publicado em 2014

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Por Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc, Lanza, Thomas J., Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Gorski, Judith N., Raustad, Kate, Wang, Sheng-Ping, Strack, Alison M., Miller, Randy, Pang, Jianmei, Madeira, Maria, Lyons, Kathy, Dragovic, Jasminka, Reitman, Marc L., Nargund, Ravi P., Lin, Linus S.
Publicado em 2012

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Por Sebhat, Iyassu K., Franklin, Christopher, Lo, Michael M.-C., Chen, David, Jewell, James P., Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M., Guan, Xiao-Ming, Marsh, Donald J., Kosinski, Jennifer A., Metzger, Joseph M., Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R., Henderson, Alan J., Reitman, Marc L., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S.
Publicado em 2010

Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats

Por Barawkar, Dinesh A., Meru, Ashwin, Bandyopadhyay, Anish, Banerjee, Abir, Deshpande, Anil M., Athare, Chandrashekhar, Koduru, Chandrasekhar, Khose, Goraksha, Gundu, Jayasagar, Mahajan, Koshu, Patil, Pradeep, Kandalkar, Sachin R., Niranjan, Sanjay, Bhosale, Shubhangi, De, Siddhartha, Mukhopadhyay, Sudit, Chaudhary, Sumit, Koul, Summon, Singh, Umesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Roy, Sophie, Graziano, Michael P., Singh, Sheo B., Cully, Doris, Cai, Tian-Quan
Publicado em 2011

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

Por Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Publicado no ACS Med Chem Lett (2015)

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Por Guo, Liangqin, Parker, Dann L., Zang, Yi, Sweis, Ramzi F., Liu, Weiguo, Sherer, Edward C., Buist, Nicole, Terebetski, Jenna, Kelly, Terri, Bugianesi, Randal, Priest, Birgit T., Dingley, Karen H., Li, Xiaofang, Mitelman, Stan, Salituro, Gino, Trujillo, Maria E., Pachanski, Michele, Kirkland, Melissa, Powles, Mary Ann, Eiermann, George J., Feng, Yue, Shang, Jin, Howard, Andrew D., Ujjainwalla, Feroze, Sinz, Christopher J., Debenham, John S., Edmondson, Scott D., Nargund, Ravi P., Hagmann, William K., Li, Derun
Publicado no ACS Med Chem Lett (2016)

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

Por He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W., Ting, Pauline C., Kuethe, Jeffrey T., Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Sperbeck, Donald M., Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Gibson, Jack T., Lisnock, JeanMarie, Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Chen, Dunlu, Chen, Xiaoli, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Publicado em 2013

Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

Por Liu, Ping, Lanza, Thomas J., Chioda, Marc, Jones, Carrie, Chobanian, Harry R., Guo, Yan, Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Ramsay, Katie, Wang, Sheng-Ping, Strack, Alison M., Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G., Schafer, Wes A., Welch, Christopher J., Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Ball, Richard G., Tsou, Nancy, Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P., Lin, Linus S.
Publicado em 2011

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

Por He, Shuwen, Hong, Qingmei, Lai, Zhong, Yang, David X., Ting, Pauline C., Kuethe, Jeffrey T., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Sonatore, Lisa M., Wiltsie, Judyann, Liu, Jinqi, Gorski, Judith N., Chung, Christine C., Gibson, Jack T., Lisnock, JeanMarie, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Publicado em 2014

A role for the melanocortin 4 receptor in sexual function

Por Van der Ploeg, Lex H. T., Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan
Publicado em 2002

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Por Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc D., Fung, Selena, Lanza, Thomas J., Chang, Linda, Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M., Krska, Shane W., Makarewicz, Amanda K., Martel, Elliot J., Leone, Joseph F., Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L., Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P., Shiao, Lin-Lin, Sullivan, Kathleen M., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S., DeVita, Robert J.
Publicado em 2014

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

Por He, Shuwen, Lai, Zhong, Ye, Zhixiong, Dobbelaar, Peter H., Shah, Shrenik K., Truong, Quang, Du, Wu, Guo, Liangqin, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James, Reibarkh, Mikhail, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei, Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.
Publicado em 2014

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Por Liu, Ping, Hamill, Terence G., Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S., Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L., Leone, Joseph F., Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A., Nargund, Ravi P., DeVita, Robert J.
Publicado em 2013

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

Por He, Shuwen, Ye, Zhixiong, Truong, Quang, Shah, Shrenik, Du, Wu, Guo, Liangqin, Dobbelaar, Peter H., Lai, Zhong, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James, Pasternak, Alexander, Feng, Zhe, deJesus, Reynalda, Yang, Lihu, Reibarkh, Mikhail, Bradley, Scott A., Holmes, Mark A., Ball, Richard G., Ruck, Rebecca T., Huffman, Mark A., Wong, Frederick, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.
Publicado em 2012

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Por Shah, Shrenik K., He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V., Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P., Hagmann, William K.
Publicado no ACS Med Chem Lett (2015)