Approaches Toward New Alzheimer's Treatments

Por Vacca, Joseph P.
Publicado em 2012

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Por Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.
Publicado em 2002

MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

Por Liverton, Nigel J., Carroll, Steven S., DiMuzio, Jillian, Fandozzi, Christine, Graham, Donald J., Hazuda, Daria, Holloway, M. Katherine, Ludmerer, Steven W., McCauley, John A., McIntyre, Charles J., Olsen, David B., Rudd, Michael T., Stahlhut, Mark, Vacca, Joseph P.
Publicado em 2010

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

Por Bell, Ian M., Gallicchio, Steven N., Wood, Michael R., Quigley, Amy G., Stump, Craig A., Zartman, C. Blair, Fay, John F., Li, Chi-Chung, Lynch, Joseph J., Moore, Eric L., Mosser, Scott D., Prueksaritanont, Thomayant, Regan, Christopher P., Roller, Shane, Salvatore, Christopher A., Kane, Stefanie A., Vacca, Joseph P., Selnick, Harold G.
Publicado em 2010

Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

Por Rudd, Michael T., McCauley, John A., Butcher, John W., Romano, Joseph J., McIntyre, Charles J., Nguyen, Kevin T., Gilbert, Kevin F., Bush, Kimberly J., Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S., DiMuzio, Jillian M., Graham, Donald J., Ludmerer, Steven W., Stahlhut, Mark W., Fandozzi, Christine M., Trainor, Nicole, Olsen, David B., Vacca, Joseph P., Liverton, Nigel J.
Publicado em 2011

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2012

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2014

Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors

Por Shah, Unmesh, Jayne, Charles, Chackalamannil, Samuel, Velázquez, Francisco, Guo, Zhuyan, Buevich, Alexei, Howe, John A., Chase, Robert, Soriano, Aileen, Agrawal, Sony, Rudd, Michael T., McCauley, John A., Liverton, Nigel J., Romano, Joseph, Bush, Kimberly, Coleman, Paul J., Grisé-Bard, Christiane, Brochu, Marie-Christine, Charron, Sylvie, Aulakh, Virender, Bachand, Benoit, Beaulieu, Patrick, Zaghdane, Helmi, Bhat, Sathesh, Han, Yongxin, Vacca, Joseph P., Davies, Ian W., Weber, Ann E., Venkatraman, Srikanth
Publicado em 2014

Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats

Por Barawkar, Dinesh A., Meru, Ashwin, Bandyopadhyay, Anish, Banerjee, Abir, Deshpande, Anil M., Athare, Chandrashekhar, Koduru, Chandrasekhar, Khose, Goraksha, Gundu, Jayasagar, Mahajan, Koshu, Patil, Pradeep, Kandalkar, Sachin R., Niranjan, Sanjay, Bhosale, Shubhangi, De, Siddhartha, Mukhopadhyay, Sudit, Chaudhary, Sumit, Koul, Summon, Singh, Umesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Roy, Sophie, Graziano, Michael P., Singh, Sheo B., Cully, Doris, Cai, Tian-Quan
Publicado em 2011

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Por Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, Fisher, Thorsten E., Embrey, Mark, Guare, James P., Egbertson, Melissa S., Vacca, Joseph P., Huff, Joel R., Felock, Peter J., Witmer, Marc V., Stillmock, Kara A., Danovich, Robert, Grobler, Jay, Miller, Michael D., Espeseth, Amy S., Jin, Lixia, Chen, I-Wu, Lin, Jiunn H., Kassahun, Kelem, Ellis, Joan D., Wong, Bradley K., Xu, Wei, Pearson, Paul G., Schleif, William A., Cortese, Riccardo, Emini, Emilio, Summa, Vincenzo, Holloway, M. Katharine, Young, Steven D.
Publicado em 2004

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Por Harper, Steven, McCauley, John A., Rudd, Michael T., Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W., Romano, Joseph J., Bush, Kimberly J., Gilbert, Kevin F., McIntyre, Charles J., Nguyen, Kevin T., Nizi, Emanuela, Carroll, Steven S., Ludmerer, Steven W., Burlein, Christine, DiMuzio, Jillian M., Graham, Donald J., McHale, Carolyn M., Stahlhut, Mark W., Olsen, David B., Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M., Rowley, Michael, Coleman, Paul J., Vacca, Joseph P., Summa, Vincenzo, Liverton, Nigel J.
Publicado em 2012

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

Por Bungard, Christopher J., Williams, Peter D., Ballard, Jeanine E., Bennett, David J., Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S., Chang, Ronald K., Dubost, David C., Fay, John F., Diamond, Tracy L., Greshock, Thomas J., Hao, Li, Holloway, M. Katharine, Felock, Peter J., Gesell, Jennifer J., Su, Hua-Poo, Manikowski, Jesse J., McKay, Daniel J., Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M., Nantermet, Philippe G., Nadeau, Christian, Sanchez, Rosa I., Satyanarayana, Tummanapalli, Shipe, William D., Singh, Sanjay K., Truong, Vouy Linh, Vijayasaradhi, Sivalenka, Wiscount, Catherine M., Vacca, Joseph P., Crane, Sheldon N., McCauley, John A.
Publicado no ACS Med Chem Lett (2016)