Kibdelomycin Is a Bactericidal Broad-Spectrum Aerobic Antibacterial Agent

Por Singh, Sheo B., Dayananth, Priya, Balibar, Carl J., Garlisi, Charles G., Lu, Jun, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Ha, Sookhee, Young, Katherine
Publicado no Antimicrob Agents Chemother (2015)

Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile

Por Miesel, Lynn, Hecht, David W., Osmolski, James R., Gerding, Dale, Flattery, Amy, Li, Fangbiao, Lan, Jing, Lipari, Philip, Polishook, Jon D., Liang, Lianzhu, Liu, Jenny, Olsen, David B., Singh, Sheo B.
Publicado em 2014

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Por Clayton, Gina M., Klein, Daniel J., Rickert, Keith W., Patel, Sangita B., Kornienko, Maria, Zugay-Murphy, Joan, Reid, John C., Tummala, Srivanya, Sharma, Sujata, Singh, Sheo B., Miesel, Lynn, Lumb, Kevin J., Soisson, Stephen M.
Publicado em 2013

Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

Por Singh, Sheo B., Liu, Weiguo, Li, Xiaohua, Chen, Tom, Shafiee, Ali, Card, Deborah, Abruzzo, George, Flattery, Amy, Gill, Charles, Thompson, John R., Rosenbach, Mark, Dreikorn, Sarah, Hornak, Viktor, Meinz, Maria, Kurtz, Myra, Kelly, Rosemarie, Onishi, Janet C.
Publicado em 2012

The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

Por Singh, Sheo B., Kang, Ling, Nawrocki, Andrea R., Zhou, Dan, Wu, Margaret, Previs, Stephen, Miller, Corey, Liu, Haiying, Hines, Catherine D. G., Madeira, Maria, Cao, Jin, Herath, Kithsiri, Wang, Liangsu, Kelley, David E., Li, Cai, Guan, Hong-Ping
Publicado no PLoS One (2016)

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Por Wu, Margaret, Singh, Sheo B., Wang, Jun, Chung, Christine C., Salituro, Gino, Karanam, Bindhu V., Lee, Sang Ho, Powles, Maryann, Ellsworth, Kenneth P., Lassman, Michael E., Miller, Corey, Myers, Robert W., Tota, Michael R., Zhang, Bei B., Li, Cai
Publicado em 2011

Design, Synthesis, and Evaluation of Prodrugs of Ertapenem

Por Singh, Sheo B., Rindgen, Diane, Bradley, Prudence, Cama, Lovji, Sun, Wanying, Hafey, Michael J., Suzuki, Takao, Wang, Nengxue, Wu, Hao, Zhang, Basheng, Wang, Li, Ji, Chongmin, Yu, Hongshi, Soll, Richard, Olsen, David B., Meinke, Peter T., Nicoll-Griffith, Deborah A.
Publicado em 2013

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

Por Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Meinke, Peter T., Olsen, David, Lagrutta, Armando, Bradley, Prudence, Lu, Jun, Patel, Sangita, Rickert, Keith W., Smith, Robert F., Soisson, Stephen, Wei, Changqing, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi
Publicado em 2014

Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

Por Darkin-Rattray, Sandra J., Gurnett, Anne M., Myers, Robert W., Dulski, Paula M., Crumley, Tami M., Allocco, John J., Cannova, Christine, Meinke, Peter T., Colletti, Steven L., Bednarek, Maria A., Singh, Sheo B., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Schmatz, Dennis M.
Publicado em 1996

Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

Por Singh, Sheo B., Kang, Ling, Nawrocki, Andrea R., Zhou, Dan, Wu, Margaret, Previs, Stephen, Miller, Corey, Liu, Haiying, Hines, Catherine D. G., Madeira, Maria, Cao, Jin, Herath, Kithsiri, Spears, Larry D., Semenkovich, Clay F., Wang, Liangsu, Kelley, David E., Li, Cai, Guan, Hong-Ping
Publicado no PLoS One (2017)

In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Por Tan, Christopher M., Gill, Charles J., Wu, Jin, Toussaint, Nathalie, Yin, Jingjun, Tsuchiya, Takayuki, Garlisi, Charles G., Kaelin, David, Meinke, Peter T., Miesel, Lynn, Olsen, David B., Lagrutta, Armando, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Oohata, Kouhei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi, Singh, Sheo B.
Publicado no Antimicrob Agents Chemother (2016)

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Por Wang, Jun, Kodali, Srinivas, Lee, Sang Ho, Galgoci, Andrew, Painter, Ronald, Dorso, Karen, Racine, Fred, Motyl, Mary, Hernandez, Lorraine, Tinney, Elizabeth, Colletti, Steven L., Herath, Kithsiri, Cummings, Richard, Salazar, Oscar, González, Ignacio, Basilio, Angela, Vicente, Francisca, Genilloud, Olga, Pelaez, Fernando, Jayasuriya, Hiranthi, Young, Katherine, Cully, Doris F., Singh, Sheo B.
Publicado em 2007

Discovery of FabH/FabF Inhibitors from Natural Products

Por Young, Katherine, Jayasuriya, Hiranthi, Ondeyka, John G., Herath, Kithsiri, Zhang, Chaowei, Kodali, Srinivas, Galgoci, Andrew, Painter, Ronald, Brown-Driver, Vickie, Yamamoto, Robert, Silver, Lynn L., Zheng, Yingcong, Ventura, Judith I., Sigmund, Janet, Ha, Sookhee, Basilio, Angela, Vicente, Francisca, Tormo, José Rubén, Pelaez, Fernando, Youngman, Phil, Cully, Doris, Barrett, John F., Schmatz, Dennis, Singh, Sheo B., Wang, Jun
Publicado em 2006

Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats

Por Barawkar, Dinesh A., Meru, Ashwin, Bandyopadhyay, Anish, Banerjee, Abir, Deshpande, Anil M., Athare, Chandrashekhar, Koduru, Chandrasekhar, Khose, Goraksha, Gundu, Jayasagar, Mahajan, Koshu, Patil, Pradeep, Kandalkar, Sachin R., Niranjan, Sanjay, Bhosale, Shubhangi, De, Siddhartha, Mukhopadhyay, Sudit, Chaudhary, Sumit, Koul, Summon, Singh, Umesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Roy, Sophie, Graziano, Michael P., Singh, Sheo B., Cully, Doris, Cai, Tian-Quan
Publicado em 2011