Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Platensimycin (PTM) is a recently discovered broad-spectrum antibiotic produced by Streptomyces platensis. It acts by selectively inhibiting the elongation-condensing enzyme FabF of the fatty acid biosynthesis pathway in bacteria. We report here that PTM is also a potent and highly selective inhibit...

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Detalhes bibliográficos
Principais autores: Wu, Margaret, Singh, Sheo B., Wang, Jun, Chung, Christine C., Salituro, Gino, Karanam, Bindhu V., Lee, Sang Ho, Powles, Maryann, Ellsworth, Kenneth P., Lassman, Michael E., Miller, Corey, Myers, Robert W., Tota, Michael R., Zhang, Bei B., Li, Cai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069196/
https://ncbi.nlm.nih.gov/pubmed/21389266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002588108
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