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Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. Comparative analysis of the PTM and PTN biosynthetic machineries in Streptomyces pla...

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Bibliografische gegevens
Hoofdauteurs: Smanski, Michael J., Yu, Zhiguo, Casper, Jeffrey, Lin, Shuangjun, Peterson, Ryan M., Chen, Yihua, Wendt-Pienkowski, Evelyn, Rajski, Scott R., Shen, Ben
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158216/
https://ncbi.nlm.nih.gov/pubmed/21825154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106919108
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