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Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis
Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. Comparative analysis of the PTM and PTN biosynthetic machineries in Streptomyces pla...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158216/ https://ncbi.nlm.nih.gov/pubmed/21825154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106919108 |
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