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Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis
Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. Comparative analysis of the PTM and PTN biosynthetic machineries in Streptomyces pla...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158216/ https://ncbi.nlm.nih.gov/pubmed/21825154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106919108 |
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