Mechanisms of self-resistance in the platensimycin and platencin producing Streptomyces platensis MA7327 and MA7339 strains

Platensimycin (PTM) and platencin (PTN) are potent inhibitors of bacterial fatty acid synthases and have emerged as promising antibacterial drug leads. We previously characterized the PTM and PTN biosynthetic machineries in the Streptomyces platensis producers. We now identify two mechanisms for PTM...

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Detaylı Bibliyografya
Asıl Yazarlar: Peterson, Ryan M., Huang, Tingting, Rudolf, Jeffrey D., Smanski, Michael J., Shen, Ben
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966621/
https://ncbi.nlm.nih.gov/pubmed/24560608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.01.005
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