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Mechanisms of self-resistance in the platensimycin and platencin producing Streptomyces platensis MA7327 and MA7339 strains

Platensimycin (PTM) and platencin (PTN) are potent inhibitors of bacterial fatty acid synthases and have emerged as promising antibacterial drug leads. We previously characterized the PTM and PTN biosynthetic machineries in the Streptomyces platensis producers. We now identify two mechanisms for PTM...

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Autori principali: Peterson, Ryan M., Huang, Tingting, Rudolf, Jeffrey D., Smanski, Michael J., Shen, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966621/
https://ncbi.nlm.nih.gov/pubmed/24560608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.01.005
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