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Engineering of Streptomyces platensis MA7339 for Overproduction of Platencin and Congeners
[Image: see text] Platensimycin (1) and platencin (2) are novel antibiotic leads against multi-drug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2855538/ https://ncbi.nlm.nih.gov/pubmed/20232845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol100342m |
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