A New Golden Age of Natural Products Drug Discovery

od Shen, Ben
Izdano u Cell (2015)

Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein

od Liu, Wen, Shen, Ben
Izdano 2000

Multifaceted Modes of Action for the Glutarimide-containing Polyketides Revealed

od Rajski, Scott R., Shen, Ben
Izdano 2010

The Bifunctional Acyltransferase/Decarboxylase LnmK as the Missing Link for-Alkylation in Polyketide Biosynthesis

od Liu, Tao, Huang, Yong, Shen, Ben
Izdano 2009

Biosynthesis of Enediyne Antitumor Antibiotics

od Van Lanen, Steven G., Shen, Ben
Izdano 2008

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates

od Adhikari, Ajeeth, Shen, Ben, Rader, Christoph
Izdano u Antib Ther (2021)

Genetic Localization and Molecular Characterization of the nonS Gene Required for Macrotetrolide Biosynthesis in Streptomyces griseus DSM40695

od Smith, Wyatt C., Xiang, Longkuan, Shen, Ben
Izdano 2000

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Host...

od Chen, Yihua, Wendt-Pienkowski, Evelyn, Shen, Ben
Izdano 2008

Characterization of the Epoxide Hydrolase NcsF2 from the Neocarzinostatin Biosynthetic Gene Cluster

od Lin, Shuangjun, Horsman, Geoffrey P., Shen, Ben
Izdano 2010

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

od Chen, Yihua, Smanski, Michael J., Shen, Ben
Izdano 2010

Genome Neighborhood Network Reveals Insights into Enediyne Biosynthesis and Facilitates Prediction and Prioritization for Discovery

od Rudolf, Jeffrey D., Yan, Xiaohui, Shen, Ben
Izdano u J Ind Microbiol Biotechnol (2015)

Challenges and Opportunities for Natural Product Discovery, Production, and Engineering in Native Producers versus Heterologous Hosts

od Teijaro, Christiana N., Adhikari, Ajeeth, Shen, Ben
Izdano u J Ind Microbiol Biotechnol (2018)

Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin in Streptomyces atroolivaceus S-140

od Cheng, Yi-Qiang, Tang, Gong-Li, Shen, Ben
Izdano 2002

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

od Cheng, Yi-Qiang, Tang, Gong-Li, Shen, Ben
Izdano 2003

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus

od Li, Wenli, Ju, Jianhua, Osada, Hiroyuki, Shen, Ben
Izdano 2006

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

od Van Lanen, Steven G., Lin, Shuangjun, Shen, Ben
Izdano 2008

Polyketide Chain Skipping Mechanism in the Biosynthesis of the Hybrid Nonribosomal Peptide-Polyketide Antitumor Antibiotic Leinamycin in Streptomyces atroolivaceus S-140

od Tang, Gong-Li, Cheng, Yi-Qiang, Shen, Ben
Izdano 2006

Regiospecific Chlorination of (S)-β-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

od Lin, Shuangjun, Van Lanen, Steven G., Shen, Ben
Izdano 2007

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

od Lin, Shuangjun, Van Lanen, Steven G., Shen, Ben
Izdano 2009

A Mutasynthetic Library of Platensimycin and Platencin Analogues

od Dong, Liao-Bin, Rudolf, Jeffrey D., Shen, Ben
Izdano u Org Lett (2016)