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Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin in Streptomyces atroolivaceus S-140

Leinamycin (LNM), produced by Streptomyces atroolivaceus, is a thiazole-containing hybrid peptide-polyketide natural product structurally characterized with an unprecedented 1,3-dioxo-1,2-dithiolane moiety that is spiro-fused to a 18-member macrolactam ring. LNM exhibits a broad spectrum of antimicr...

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Detalhes bibliográficos
Main Authors: Cheng, Yi-Qiang, Tang, Gong-Li, Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135466/
https://ncbi.nlm.nih.gov/pubmed/12446651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.24.7013-7024.2002
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