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Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin Biosynthesis
[Image: see text] Leinamycin (LNM) is biosynthesized by a hybrid nonribosomal peptide synthetase (NRPS)–acyltransferase (AT)-less type I polyketide synthase (PKS). Characterization of LnmI revealed ketosynthase (KS)–acyl carrier protein (ACP)–KS domains at the NRPS–PKS interface. Inactivation of the...
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| Publicado en: | Org Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical Society
2016
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5013926/ https://ncbi.nlm.nih.gov/pubmed/27541042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02033 |
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