Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin Biosynthesis

[Image: see text] Leinamycin (LNM) is biosynthesized by a hybrid nonribosomal peptide synthetase (NRPS)–acyltransferase (AT)-less type I polyketide synthase (PKS). Characterization of LnmI revealed ketosynthase (KS)–acyl carrier protein (ACP)–KS domains at the NRPS–PKS interface. Inactivation of the...

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Détails bibliographiques
Publié dans:Org Lett
Auteurs principaux: Huang, Yong, Tang, Gong-Li, Pan, Guohui, Chang, Chin-Yuan, Shen, Ben
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013926/
https://ncbi.nlm.nih.gov/pubmed/27541042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02033
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