Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

[Image: see text] Biochemical studies of purified and dissected fungal polyketide synthase and nonribosomal peptide synthetase (PKS-NRPS) hybrid enzymes involved in biosynthesis of pseurotin and aspyridone indicate that one α-methylation step during polyketide synthesis is a prerequisite and a key c...

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Bibliographic Details
Published in:Org Lett
Main Authors: Zou, Yi, Xu, Wei, Tsunematsu, Yuta, Tang, Mancheng, Watanabe, Kenji, Tang, Yi
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275151/
https://ncbi.nlm.nih.gov/pubmed/25494235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503179v
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