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Unique features of the ketosynthase domain in a nonribosomal peptide synthetase–polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1

Many microbial secondary metabolites are produced by multienzyme complexes comprising nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). The ketosynthase (KS) domains of polyketide synthase normally catalyze the decarboxylative Claisen condensation of acyl and malonyl blocks t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yun, Choong-Soo, Nishimoto, Kazuki, Motoyama, Takayuki, Shimizu, Takeshi, Hino, Tomoya, Dohmae, Naoshi, Nagano, Shingo, Osada, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450107/
https://ncbi.nlm.nih.gov/pubmed/32565425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013105
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