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Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners
Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. We have previously cloned and sequenced the PTM-PTN dual biosynthetic gene cluster f...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532557/ https://ncbi.nlm.nih.gov/pubmed/23157615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np3005985 |
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