Llwytho...

Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners

Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. We have previously cloned and sequenced the PTM-PTN dual biosynthetic gene cluster f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Smanski, Michael J., Casper, Jeffrey, Peterson, Ryan M., Yu, Zhiguo, Rajski, Scott R., Shen, Ben
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532557/
https://ncbi.nlm.nih.gov/pubmed/23157615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np3005985
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