Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

[Image: see text] Ilicicolin H is a polyketide—nonribosomal peptide synthase (NRPS)—natural product isolated from Gliocadium roseum, which exhibits potent and broad spectrum antifungal activity, with sub-μg/mL MICs against Candida spp., Aspergillus fumigatus, and Cryptococcus spp. It showed a novel...

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Auteurs principaux: Singh, Sheo B., Liu, Weiguo, Li, Xiaohua, Chen, Tom, Shafiee, Ali, Card, Deborah, Abruzzo, George, Flattery, Amy, Gill, Charles, Thompson, John R., Rosenbach, Mark, Dreikorn, Sarah, Hornak, Viktor, Meinz, Maria, Kurtz, Myra, Kelly, Rosemarie, Onishi, Janet C.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025731/
https://ncbi.nlm.nih.gov/pubmed/24900384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300173e
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