Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

[Image: see text] Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to inhibition by diverse classes of i...

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Detalhes bibliográficos
Main Authors: Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Meinke, Peter T., Olsen, David, Lagrutta, Armando, Bradley, Prudence, Lu, Jun, Patel, Sangita, Rickert, Keith W., Smith, Robert F., Soisson, Stephen, Wei, Changqing, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027601/
https://ncbi.nlm.nih.gov/pubmed/24900889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500069w
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