Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Emergence of bacterial resistance is a major issue for all classes of antibiotics; therefore, the identification of new classes is critically needed. Recently we reported the discovery of platensimycin by screening natural product extracts using a target-based whole-cell strategy with antisense sile...

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Bibliografski detalji
Glavni autori: Wang, Jun, Kodali, Srinivas, Lee, Sang Ho, Galgoci, Andrew, Painter, Ronald, Dorso, Karen, Racine, Fred, Motyl, Mary, Hernandez, Lorraine, Tinney, Elizabeth, Colletti, Steven L., Herath, Kithsiri, Cummings, Richard, Salazar, Oscar, González, Ignacio, Basilio, Angela, Vicente, Francisca, Genilloud, Olga, Pelaez, Fernando, Jayasuriya, Hiranthi, Young, Katherine, Cully, Doris F., Singh, Sheo B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1863502/
https://ncbi.nlm.nih.gov/pubmed/17456595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700746104
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